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Throat & Thyroid

Underactive Thyroid: Spot the Symptoms, Understand Your Numbers, Take Action

Updated: 08/13/2026·8 min read·Medically reviewed
Daniel Lindenthal
Daniel LindenthalPhysician · Private practice Stuttgart
A woman’s neck – home of the thyroid, the body’s metabolism gland

Always tired even though you sleep enough? You’re cold while others are sweating? Gaining weight although you don’t eat more than before? Surprisingly often, this combination comes down to a small gland with a big effect: the thyroid. When it works too slowly, your whole metabolism slows down – gradually, over months, which is why it often goes unnoticed for a long time. The good news: an underactive thyroid is easy to detect and usually responds well to treatment.

Key takeaways

  • With an underactive thyroid (hypothyroidism), the gland produces too little hormone – your metabolism runs on low.
  • Typical symptoms: fatigue, feeling cold, weight gain, dry skin, hair loss, constipation and low mood.
  • The most important screening test is the TSH level in your blood – it often flags a problem before you have clear symptoms.
  • The most common cause in Germany is the autoimmune disease Hashimoto’s thyroiditis.
  • Treatment with thyroid hormone is well established – most people live a completely normal life with it.

What is an underactive thyroid?

The thyroid is a butterfly-shaped gland below the voice box – hardly bigger than a walnut, but the pacemaker of your entire metabolism. Its hormones (T3 and T4) affect energy use, heartbeat, body temperature, digestion, mood and concentration. Production is controlled by the hormone TSH from the pituitary gland: if the thyroid produces too little, the TSH level rises – the brain “calls” louder for hormones, so to speak.

With an underactive thyroid (hypothyroidism), the gland no longer answers that call well enough. The body switches into energy-saving mode: everything slows down – your pulse, your digestion, your thinking, even the regrowth of skin and hair. Because this develops gradually over months, many people first blame their symptoms on stress, age or the weather.

Typical symptoms: when your body runs on low

No two people experience an underactive thyroid the same way – pay attention if several of the following signs come together and last for weeks:

  • Fatigue and exhaustion: a leaden lack of drive despite enough sleep – often the first and most stubborn symptom.
  • Feeling cold and sensitive to cold: you’re cold where others are comfortable; cold hands and feet are constant companions.
  • Weight gain: your weight goes up even though nothing has changed about your diet or exercise.
  • Dry skin and hair loss: your skin becomes rough and pale, your hair thinner and brittle – sometimes the outer eyebrows thin out, too.
  • Constipation: sluggish digestion is a direct result of the slowed metabolism.
  • Low mood and trouble concentrating: lack of drive, “brain fog” and forgetfulness can look very much like depression.
  • Slow pulse and low blood pressure: your heart shifts down a gear, too.
  • Irregular periods and trouble getting pregnant: in women, hormone balance can get out of rhythm – which is why the thyroid is part of the basic work-up.

Women are affected far more often than men, and the likelihood rises with age. During and after menopause in particular, the symptoms are often misread – so a look at the thyroid is doubly worthwhile here.

Causes: how an underactive thyroid develops

  • Hashimoto’s thyroiditis: by far the most common cause. The immune system turns against the body’s own thyroid and weakens it over years – more on this in our separate Hashimoto’s guide.
  • After treatments: thyroid surgery or radioactive iodine therapy can permanently reduce hormone production – this is expected and is deliberately compensated for.
  • Medications: certain drugs, such as some heart or psychiatric medications, can affect thyroid function.
  • Iodine deficiency: less common today, but still relevant – the thyroid needs iodine as a building block for its hormones.

Good to know: Often, a subclinical (latent) underactive thyroid is found first: the TSH level is raised, but the actual thyroid hormones are still normal. Whether to start treatment at this stage depends on your symptoms, age and circumstances – there’s no one-size-fits-all answer, but there is a good individual one.

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TSH and more: understanding your numbers

The most important screening test is the TSH level in your blood. It’s very sensitive: TSH rises even before the actual thyroid hormones measurably drop. If the TSH level is abnormal, the free thyroid hormone fT4 is measured as well – only the combination allows a proper interpretation:

A simplified guide (reference ranges vary slightly from lab to lab):

TSH normal
Normal function
TSH ↑, fT4 normal
Mild (subclinical)
TSH ↑, fT4 ↓
Overt (established)

Important for interpretation: a single, slightly raised TSH level is not yet a diagnosis – the value changes with the time of day, infections and other factors, and should be confirmed with a follow-up test. That’s exactly why a good work-up always includes both: the numbers and a look at the person behind them.

How we check it at our practice

At Privatpraxis Lindenthal on Rotebühlplatz in Stuttgart, we take time for the whole picture – instead of leaving you alone with a number:

  • A detailed conversation: your symptoms, how they developed, medications, family history – the medical history often provides the decisive clues.
  • Thyroid exam: size, texture and possible nodules can be assessed well by feeling your neck – painless and done in a few minutes.
  • Physical exam: pulse, blood pressure, skin and reflexes give additional clues about how much your metabolism is affected.
  • Review of your lab results: just bring any results you have (TSH, fT4) – we translate them into plain language and tell you honestly which tests would make sense and where you can have them done.
  • A clear recommendation: you find out whether treatment is advisable and what the next steps are – and we coordinate further testing if needed.
Examining the neck – the thyroid can be felt easily

Treatment: a normal life on the right dose

The standard treatment for an underactive thyroid is taking thyroid hormone (levothyroxine) – as a tablet, in the morning on an empty stomach, at a dose adjusted to you. This gives your body exactly the hormone it’s missing. The dose is adjusted step by step and checked with follow-up TSH tests; it can take a few weeks to find the right setting. On the right dose, the vast majority of people live a completely normal life without limitations.

Your part: take the tablets consistently and correctly (about 30 minutes before breakfast, not together with calcium or iron supplements), keep your follow-up appointments – and mention changes such as a racing heart, restlessness or returning fatigue, so the dose can be adjusted.

When to act right away

In rare cases, a severe untreated underactive thyroid can become dangerous. Act immediately if you have a known underactive thyroid and the following occurs:

  • Increasing drowsiness or confusion, up to complete unresponsiveness
  • A very slow heartbeat and unusually low body temperature
  • Pronounced swelling with shallow, slowed breathing

These can be signs of a severe metabolic crisis:

Call 112 (emergency)

“The thyroid is small, quiet and easy to overlook – yet it explains many a fatigue that people blame themselves for, for years.”

Daniel Lindenthal, Physician

Frequently asked questions about an underactive thyroid

What are the typical symptoms of an underactive thyroid?
The typical combination is ongoing fatigue, feeling cold, weight gain, dry skin, hair loss, constipation and low mood. A slow pulse, trouble concentrating and irregular periods can be part of it, too. The symptoms usually develop gradually over months.
Which lab value shows an underactive thyroid?
The most important screening test is the TSH level in your blood: it rises when the thyroid produces too little hormone. To interpret it, the free thyroid hormone fT4 is measured as well. A single slightly raised value should be confirmed with a follow-up test before a diagnosis is made.
What is a subclinical (latent) underactive thyroid?
In a subclinical (latent) underactive thyroid, the TSH level is raised but the actual thyroid hormones are still in the normal range. Whether to treat depends on your symptoms, age, plans to have children and other conditions – your doctor decides this with you individually.
Can an underactive thyroid go away again?
That depends on the cause. Temporary forms – for example after a thyroid inflammation or in the months after giving birth – can resolve. The most common cause, Hashimoto’s, usually leads to a permanent underactive thyroid that can be balanced well with thyroid hormone.
Where can I get my thyroid checked in Stuttgart?
At Privatpraxis Lindenthal on Rotebühlplatz in central Stuttgart, we check a suspected underactive thyroid step by step – with a detailed conversation, a thyroid exam, a physical exam and a plain-language review of your lab results. Same-day appointments are usually available.

Sources

  1. Institute for Quality and Efficiency in Health Care (IQWiG): gesundheitsinformation.de – Underactive thyroid. gesundheitsinformation.de
  2. German Society of Endocrinology (DGE): Patient information on thyroid diseases. endokrinologie.net
  3. German Thyroid League (Schilddrüsen-Liga Deutschland e. V.): Information on hypothyroidism. schilddruesenliga.de
This article is for general information only. It does not replace personal medical advice, diagnosis or treatment. If you have symptoms, please contact the practice directly.
Daniel Lindenthal
Daniel Lindenthal

Physician and founder of Privatpraxis Lindenthal in Stuttgart. His standard: fair, transparent care that treats you as an equal.

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